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[目的]观察柴胡加龙骨牡蛎汤对急性心理应激大鼠旷场行为和血浆促肾上腺皮质激素的影响。[方法]采用大鼠急性心理应激动物模型,在应激前用两种不同浓度的柴胡加龙骨牡蛎汤胃饲7d,观察心理应激后血浆促肾上腺皮质激素含量的动态变化以及大鼠旷场行为的改变,并与对照组相比较。[结果]与正常对照组比较,应激大鼠在旷场中的穿行格数和直立次数明显增加,血浆促肾上腺皮质激素浓度显著升高,而两种不同浓度的给药,对此反应均有抑制作用。[结论]柴胡加龙骨牡蛎汤对急性心理应激大鼠的心理行为反应和生理反应具有调节作用。
[Objective] To observe the effects of Chaihu Plus Longgu oyster decoction on open-field behavior and plasma adrenocorticotropic hormone in rats with acute psychological stress. [Methods] Rat acute psychological stress animal model was used. Before and after stress, two different concentrations of Chaihu plus Longgu oyster soup were used for stomach feeding for 7 days to observe the dynamic changes of plasma adrenocorticalotropic hormone levels and rats after psychological stress. The behavior of the market was changed and compared with the control group. [Results] Compared with the normal control group, stress rats significantly increased in number and number of erections in the open field, plasma corticosterone concentrations increased significantly, and two different concentrations of the administration, the response were There is inhibition. [Conclusion] Chaihu plus Longgu oyster decoction can regulate the psychological and behavioral responses and physiological responses of rats with acute psychological stress.