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目的探讨美沙拉嗪肠溶片治疗溃疡性结肠炎的临床疗效。方法对60例经内镜检查确诊为轻、中度溃疡性结肠炎急性期的患者,随机分成治疗组(n=30)和对照组(n=30),分别给予美沙拉嗪肠溶片、柳氮磺胺吡啶治疗。治疗4周和8周观察疗效。结果治疗组患者治疗4、8周疗效分别为60.0%、86.7%,明显优于对照组的36.7%、66.7%,差异有统计学意义(P<0.01)。结论美沙拉嗪肠溶片是治疗溃疡性结肠炎安全有效的药物。
Objective To investigate the clinical efficacy of mesalazine enteric-coated tablets in the treatment of ulcerative colitis. Methods Sixty patients diagnosed as mild to moderate ulcerative colitis by endoscopy were randomly divided into treatment group (n = 30) and control group (n = 30), and were given mesalazine enteric-coated tablets, Sulfasalazine treatment. The curative effect was observed after 4 weeks and 8 weeks of treatment. Results The curative effect of treatment group for 4 and 8 weeks were 60.0% and 86.7% respectively, which was significantly better than that of control group (36.7% and 66.7%, P <0.01). Conclusion Mesalazine enteric-coated tablets are safe and effective for the treatment of ulcerative colitis.