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牙周病是局部炎症破坏性疾病,是人类最常见的口腔疾病之一。与全身给药相比,牙周局部缓释给药系统不仅使药物在牙周袋内达到高浓度,持续杀灭牙周致病菌,而且可以减少全身给药造成的不良反应和细菌耐药性。因此运用局部缓释给药系统治疗牙周病已成为国内外的研究热点,目前已有纤维剂、膜剂、微球、缓释凝胶、棒剂和口腔黏膜粘附片等牙周局部缓释给药系统在临床中使用或已有文献报道。文中主要围绕治疗牙周病的各种局部给药剂型的处方设计原理、关键辅料性质及其制剂优缺点等,详细综述牙周局部缓释给药系统的研究进展。
Periodontal disease is a devastating local inflammation and is one of the most common oral diseases in humans. Compared with systemic administration, the periodontal local slow release delivery system not only allows the drug to reach high concentrations in the periodontal pocket but also continues to kill periodontal pathogens while reducing the adverse reactions and bacterial resistance caused by systemic administration Sex. Therefore, the use of local drug delivery system for the treatment of periodontal disease has become a research hotspot at home and abroad, there are currently fibrinolytic agents, microspheres, sustained release gel, sticks and oral mucosa adhesions and other periodontal local slow Drug delivery systems are used clinically or have been reported in the literature. This article focuses on the treatment of periodontal topical formulations of various formulations of the principle of design, the nature of the key materials and the advantages and disadvantages of the preparation, etc., a detailed review of the periodontal local slow release drug delivery system research.