论文部分内容阅读
钙质沉着是结缔组织病(CTD)常见的临床表现之一,常出现于结构受损、血管异常或缺血后的组织中,在系统性红斑狼疮(SLE),系统性硬化(SSc),皮肌炎等自身免疫性疾病中表现显著。本文总结了CTD相关钙质沉积的分类、病理特点、临床表现和治疗手段。因钙质沉着的发病机制未明,病理学特征不典型且临床表现也不尽相同,到目前为止,钙质沉着的治疗仍然是一个重大挑战。因此,CTD相关钙质沉着的规范化诊断和治疗还需要更加全面和系统的临床试验与验证,这对于优化治疗疗效,降低治疗成本,提高患者的生存率和降低复发风险具有重要的意义。
Calcification is one of the common clinical manifestations of connective tissue disease (CTD), often found in tissues with structurally impaired or abnormal blood vessels or after ischemia, and plays a key role in the pathogenesis of systemic lupus erythematosus (SLE), systemic sclerosis Dermatomyositis and other autoimmune diseases in the performance of significant. This article summarizes the classification of CTD-related calcifications, pathological features, clinical manifestations and treatment. The pathogenesis of calcinosis is unknown, pathological features are not typical and clinical manifestations are not the same, so far, the treatment of calcific remains a major challenge. Therefore, the standardized diagnosis and treatment of CTD related calcifications also need more comprehensive and systematic clinical trials and verification, which is of great significance for optimizing treatment efficacy, reducing treatment costs, improving patient survival and reducing the risk of relapse.