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目的评价开同合并低蛋白饮食干预对慢性肾脏疾病(CKD)患者营养状况及肾功能的改善效果。方法以60例CKD住院患者为研究对象,随机分为两组,对照组30例,给予低蛋白饮食即每人每天供给0.6g蛋白质;实验组30例,在给予低蛋白饮食的同时补充开同,按0.2g/(kg·d)分3次餐中整服,两组均持续干预3个月,观察患者体重、上臂围(MAC)、上臂肌围(MAMC)及血清白蛋白(ALB)、前白蛋白(PA)、血清转铁蛋白(Tf)、尿素氮(BUN)、肌酐(Cr)浓度的变化。结果与对照组比较,实验组患者体重、MAC、MAMC增加(P<0.01);血清ALB、PA、Tf含量升高(P<0.01);血清BUN、Cr浓度下降(P<0.01)。结论开同合并低蛋白饮食较单纯低蛋白饮食能明显改善CKD患者的营养状况,延缓CKD的进展。
Objective To evaluate the nutritional status and renal function in patients with chronic kidney disease (CKD) treated with low protein diet intervention. Methods 60 cases of CKD hospitalized patients were randomly divided into two groups, the control group of 30 patients given low protein diet that is 0.6g protein per person per day; the experimental group of 30 patients, while giving the low protein diet supplemented open with the The patients were divided into three groups according to 0.2g / (kg · d) administration. The patients in each group received continuous intervention for 3 months. The body weight, upper arm circumference (MAC), upper arm muscular circumference (MAMC) and serum albumin (ALB) , Prealbumin (PA), serum transferrin (Tf), blood urea nitrogen (BUN) and creatinine (Cr) were measured. Results Compared with the control group, the body weight, MAC and MAMC in the experimental group increased (P <0.01), the contents of ALB, PA and Tf in the experimental group increased (P <0.01) and the concentrations of BUN and Cr decreased (P <0.01). Conclusions The combination of low protein diet with simple hypoproteinemic diet can significantly improve the nutritional status of CKD patients and delay the progression of CKD.