目的了解乌海市健康人群国家免疫规划疫苗接种后的抗体水平状况,评价疫苗接种质量效果,及时发现免疫薄弱地区,为疫苗针对疾病的控制提供科学依据。方法采用分层随机抽样方法对乌海市367人,采用酶联免疫法对其进行脊灰、麻疹、风疹、腮腺炎、百日咳、白喉、破伤风、甲肝Ig G抗体和乙肝表面抗体的检测。结果 367人中,抗体总阳性率最高的是脊灰和甲肝,均为98.37%,最低的是百日咳,为56.95%;不同年龄组间HBs Ab、麻疹、风疹、腮腺炎、百日咳、白喉和破伤风Ig G抗体阳性率差异均有统计学意义(P<0.01);不同性别间腮腺炎、白喉和破伤风Ig G抗体阳性率差异均有统计学意义(χ~2=50.97,22.01,8.63,P<0.01);不同地区间HBs Ab、脊灰、麻疹、风疹、腮腺炎、百白破、白喉、破伤风和甲肝Ig G抗体阳性率差异均无统计学意义(P>0.05)。结论乌海市健康人群免疫状况良好,脊灰、麻疹、甲肝、风疹、腮腺炎、破伤风和白喉Ig G抗体阳性率均≥80%,建立了有效的免疫屏障,但乙肝、百日咳免疫水平较低,应加强疫苗接种和定期开展抗体监测。 Objective To understand the status of antibodies in immunization programs of healthy population in Wuhai City after vaccination, evaluate the quality of vaccination and find immunocompromised areas in time, and provide a scientific basis for the control of vaccines against diseases. Methods Stratified random sampling method was used to detect the IgA and hepatitis B surface antigen of 367 people in Wuhai City by enzyme-linked immunosorbent assay (ELISA) for polio, measles, rubella, parotitis, pertussis, diphtheria, tetanus, hepatitis A and hepatitis B virus. Results Among the 367 patients, the highest positive rate of antibody was poliovirus and hepatitis A, both of which were 98.37% and the lowest was pertussis, which was 56.95%. HBs Ab, measles, rubella, mumps, whooping cough, diphtheria and broken The positive rates of Ig G antibodies in colds were statistically significant (P <0.01). The positive rates of Ig G antibodies in mumps, diphtheria and tetanus were statistically significant (χ ~ 2 = 50.97,22.01,8.63, P <0.01). There was no significant difference in the positive rates of HBs Ab, poliomyelitis, measles, rubella, mumps, diphtheria, diphtheria, tetanus and hepatitis A IgG among different regions (P> 0.05). Conclusion The immune status of healthy people in Wuhai is good, and the positive rates of IgG antibodies of polio, measles, hepatitis A, rubella, parotitis, tetanus and diphtheria are all above 80%, and the effective immune barrier is established. Low, should be strengthened vaccination and regular antibody surveillance.