论文部分内容阅读
目的观察美托洛尔联合缬沙坦治疗高血压合并左室舒张功能减退的疗效。方法选取高血压病合并左室舒张功能降低患者106例,随机分为观察组和对照组各53例,观察组给予美托洛尔联用缬沙坦治疗,对照组给予缬沙坦治疗,疗程12个月,比较2组治疗前后血压、心脏舒张末左室内径(LVDd)、左室重量指数(LVMI)、E/A等指标。结果治疗后2组患者LVDd、LVMI、DBP、SBP、E/A均优于治疗前,且观察组指标情况优于对照组,差异均有统计学意义(P<0.01)。2组不良反应比较差异无统计学意义(P>0.05)。结论美托洛尔联合缬沙坦治疗对改善高血压病患者左心室舒张功能减退的疗效明显优于单用缬沙坦治疗。
Objective To observe the efficacy of metoprolol combined with valsartan in the treatment of hypertension and left ventricular diastolic dysfunction. Methods A total of 106 patients with hypertension and left ventricular diastolic dysfunction were selected and randomly divided into observation group and control group with 53 cases in each group. The observation group was given metoprolol combined with valsartan and the control group with valsartan. The blood pressure, left ventricular end-diastolic dimension (LVDd), left ventricular mass index (LVMI) and E / A were compared between the two groups before and after treatment. Results After treatment, LVDd, LVMI, DBP, SBP and E / A in both groups were better than those before treatment, and the indexes in the observation group were better than those in the control group (P <0.01). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion The combination of metoprolol and valsartan is superior to valsartan alone in the treatment of hypertensive patients with left ventricular diastolic dysfunction.