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[目的]研究SOX4及p53在胃癌组织中的表达,探讨其生物学行为在胃癌发生、发展中的作用。[方法]收集胃癌标本120例,另取30例同期胃镜检查无癌变病变患者的正常胃黏膜,并经病理证实无明显炎症改变的标本作为对照。采用免疫组化技术检测SOX4及p53表达情况,分析SOX4及p53表达与胃癌患者性别、年龄、分化程度、浸润深度等的关系。[结果 ]胃癌组织中SOX4及p53的表达率(51.7%和87.5%)显著高于对照组(0和3.3%)(P<0.05),SOX4在低分化胃癌、61~76岁年龄组和Ⅱ期的表达率显著高于高分化组、其他年龄段组和Ⅰa~Ⅰb期(P<0.05);p53的表达率在胃癌Ⅱ期和Ⅲa~Ⅳ期阳性表达率高于Ⅰa~Ⅰb期(P<0.05)。胃癌组织中SOX4与p53表达未见相关性(r=2.30,P>0.05)。[结论 ]胃癌组织中SXO4与p53表达上调,两者没有相关性;SXO4表达与胃癌发生发展相关。
[Objective] To investigate the expression of SOX4 and p53 in gastric cancer and to explore the role of biological behavior in the development and progression of gastric cancer. [Method] Totally 120 gastric cancer specimens were collected, and the other 30 normal gastric mucosa of patients with no cancerous lesions under endoscopy were collected. The specimens with no obvious inflammatory changes confirmed by pathology were taken as control. The expression of SOX4 and p53 was detected by immunohistochemistry. The relationship between the expression of SOX4 and p53 and the gender, age, differentiation, depth of invasion of gastric cancer patients was analyzed. [Results] The expression rates of SOX4 and p53 (51.7% and 87.5%) in gastric cancer tissues were significantly higher than those in control subjects (0 and 3.3%, P <0.05). SOX4 expression in poorly differentiated gastric cancer, The expression rates of p53 in stage Ⅱa and Ⅲa ~ Ⅳ were significantly higher than those in stage Ⅰa ~ 1b (P <0.05). The positive rate of p53 in stage Ⅰa ~ <0.05). There was no correlation between the expression of SOX4 and p53 in gastric cancer (r = 2.30, P> 0.05). [Conclusion] The expressions of SXO4 and p53 are up-regulated in gastric cancer tissues. There is no correlation between them. The expression of SXO4 is correlated with the occurrence and development of gastric cancer.