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成功开发出一种直接合成N-苯基苯并咪唑的新方法.在不使用金属催化剂与强碱的条件下,通过苯并咪唑与二苯基碘三氟甲磺酸盐的反应合成了目标化合物,采用1H NMR与13C NMR技术对目标化合物进行了表征,并确定了最佳反应条件.在苯并咪唑与二苯基碘三氟甲磺酸盐的物质的量比为1∶1.2、溶剂乙醇/二甲苯的体积比为1∶4、反应温度为120℃、反应时间为24 h的最佳反应条件下,使目标化合物的产率达到了52.0%,并回收了等量的碘苯.此外,通过高效液相色谱技术进行跟踪监测,对该反应的机理进行了探讨.
Successfully developed a new direct synthesis of N-phenylbenzimidazole method.Under the conditions of metal catalyst and strong base, through the reaction of benzimidazole and diphenyliodonium triflate synthesized target The compounds were characterized by 1H NMR and 13C NMR techniques and the optimum reaction conditions were determined.The optimum reaction conditions were as follows: the molar ratio of benzimidazole to diphenyliodonium triflate was 1: 1.2, the solvent Ethanol and xylene at a volume ratio of 1: 4, reaction temperature of 120 ℃ and reaction time of 24 h, the yield of the target compound reached 52.0%, and the same amount of iodobenzene was recovered. In addition, the mechanism of this reaction was discussed through the follow-up monitoring by HPLC.