In the design process of globoidal CAM mechanism, there are some shortcomings such as long structure design cycle, low efficiency, and no modification flexibility of parameters of similar parts. NX Open classic application programming interfaces ( APIS) can be connected with Microsoft Visual Studio ( VS) . Based on NX Open application, users can develop menus, toolbars, dialog boxes and other tools to realize interactive design. Users can also call input parameters through the dialog box callback function, then activate the corresponding control application ( callback function) by C++programming language and NX Open API complete code. Based on the secondary development function of UG software and VS, a digital design system suitable for high efficiency modeling of globoidal indexing CAM mechanism was developed to complete the human-machine interface interaction design. The results show that comparing the digital design system with the traditional design, the system after parametric design can not only greatly shorten the design time, but also reduce the tedious repetitive work, which proves the superiority and feasibility of the digital design.