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目的探讨C反应蛋白(CRP)、降钙素原(PCT)及白细胞、血小板计数在新生儿败血症早期诊断中的应用价值。方法采用免疫比浊法测定CRP、酶联荧光分析技术测定PCT、5 differ血细胞分析仪计数白细胞与血小板,观察各项指标诊断新生儿败血症灵敏度、特异度,分析ROC曲线。采用Binary Logistic回归建立预测概率模型,获得新的统计量,计算各曲线下面积(AUC),获得最佳诊断点。结果新生儿败血症组CRP和PCT的阳性率较非感染组显著升高(P<0.05),AUC分别为0.676、0.690。CRP、PCT联合WBC检测的AUC为0.856。结论 CRP和PCT对新生儿败血症的早期诊断有重要意义,CRP、PCT联合WBC可提高诊断的灵敏性和特异性。
Objective To investigate the clinical value of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count and platelet count in the early diagnosis of neonatal sepsis. Methods Immunoprecipitation assay was used to measure CRP. PCT and 5 - NIF analyzer were used to count the leucocytes and platelets. The sensitivity and specificity of various indexes in diagnosing neonatal sepsis were observed. The ROC curve was analyzed. Binary Logistic regression was used to establish the predictive probability model, and new statistics were obtained. The area under each curve (AUC) was calculated to obtain the best diagnostic point. Results The positive rates of CRP and PCT in neonatal sepsis group were significantly higher than those in non-infected group (P <0.05), and the AUC were 0.676 and 0.690 respectively. The AUC of CRP and PCT in combination with WBC was 0.856. Conclusion CRP and PCT are important for early diagnosis of neonatal sepsis. CRP and PCT combined with WBC can improve the sensitivity and specificity of diagnosis.