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目的探讨高同型半胱氨酸血症(HHcy)与急性脑梗死之间的关系及临床意义。方法检测128例急性脑梗死患者和66例正常人血浆Hcy水平,通过荧光生化法定量检测血中同型半胱氨酸(Hcy)的浓度。并对急性脑梗死患者进行临床神经功能缺损程度评分。结果急性脑梗死组血浆Hcy水平明显高于对照组(P<0.05),且中型及重型血浆Hcy水平明显高于轻型(P<0.05),重型血浆Hcy水平明显高于中型(P<0.05)。结论高同型半胱氨酸是急性脑梗死的一个独立危险因素,且血浆Hcy水平越高,神经功能缺损程度越严重。
Objective To investigate the relationship between hyperhomocysteinemia (HHcy) and acute cerebral infarction and its clinical significance. Methods Plasma Hcy levels were measured in 128 patients with acute cerebral infarction and 66 healthy controls. The concentration of homocysteine (Hcy) in serum was quantitatively determined by fluorescence biochemistry. And clinical patients with acute cerebral infarction neurological deficit score. Results The level of Hcy in acute cerebral infarction group was significantly higher than that in control group (P <0.05). The levels of Hcy in moderate and severe plasma were significantly higher than those in mild (P <0.05) and the levels of Hcy in severe plasma were significantly higher than those in moderate (P <0.05). Conclusion Homocysteine is an independent risk factor for acute cerebral infarction. The higher the plasma homocysteine levels, the more severe the neurological deficits.