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目的研究低钙离子浓度透析液对维持性血液透析患者透析过程中血压、血清钙离子(Ca2+)、内皮素(ET-1)的影响。方法选择2007年3月至2008年3月中国医科大学附属盛京医院60例透析过程中血压升高的尿毒症患者,先后使用钙离子浓度为1.75mmol/L(DCa1.75)和1.25mmol/L(DCa1.25)的透析液进行血液透析,监测透析前后血压、血Ca2+、ET-1的变化。结果透析过程中血压升高的尿毒症患者应用DCa1.75的透析液,透析后的血压、血Ca2+、ET-1比透析前以及使用DCa1.25的透析液透析后血压、血Ca2+、ET-1浓度均明显升高(P<0.05)。结论应用低钙透析液能够避免高钙透析液导致的血液透析过程中血压升高问题。
Objective To investigate the effects of low calcium ion dialysate on blood pressure, serum Ca2 +, ET-1 during dialysis in maintenance hemodialysis patients. Methods From March 2007 to March 2008, 60 patients with elevated blood pressure during dialysis in Shengjing Hospital of China Medical University were treated with calcium ion concentration of 1.75mmol / L (DCa1.75) and 1.25mmol / L (DCa1.25) hemodialysis dialysate, monitoring of blood pressure before and after dialysis, blood Ca2 +, ET-1 changes. Results Dialysis of DCa1.75, dialysis, dialysis of blood Ca2 +, ET-1 before dialysis and dialysis of DCa1.25 after dialysis were used in patients with uremia with elevated blood pressure during dialysis. Blood pressure, blood Ca2 +, ET- 1 concentrations were significantly increased (P <0.05). Conclusions The use of low-calcium dialysate avoids the problem of elevated blood pressure during hemodialysis caused by high-calcium dialysate.