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目的 分析女性真性性早熟 (ICPP)患者的临床特点、探讨该病的诊断、治疗方法。方法 对1984年以来的 32例ICPP患者进行回顾性分析。结果 绝大多数ICPP患儿在月经来潮前都有不同程度的乳房发育、阴道分泌物增加等早期征象 ;而且身高也大多超出同龄人。结论 应重视ICPP患儿的早期临床征象 ,对疑似者尽早行GnRH兴奋试验。促性腺激素释放激素的衍生物 (GnRH -A)治疗ICPP ,不仅疗效显著 ,而且可明显改善患者的身高。
Objective To analyze the clinical features of female patients with true precocious puberty (ICPP) and discuss the diagnosis and treatment of the disease. Methods A retrospective analysis of 32 patients with ICPP since 1984 was performed. Results Most ICPP children had different degrees of breast development before menstruation, such as early signs of increased vaginal discharge; but also mostly beyond their peers. Conclusion Early clinical signs of ICPP should be emphasized, and the suspected GnRH excitatory test should be conducted as soon as possible. GnRH-A, a derivative of gonadotropin-releasing hormone, is not only effective but also significantly improves the patient’s height.