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家兔配后1天灌服抗孕-53(10.5mg/kg),第11天剖腹检查,对照组着床数为9.7±1.6(平均值±SEM),实验组为0.4±0.4;兔妊娠第7—9天连续灌服抗孕-53(每天5mg/kg),17天剖检,对照组活胎数为7.5±1.1,实验组活胎数为0.3±0.3,死胎数为7.0±0.5;兔妊娠第22天肌肉注射抗孕-53(1.25mg/kg)一针,30天剖检,对照组活胎数为12.2±0.2,实验组均为死胎11.9±0.5。说明抗孕-53有明显抗着床、抗早孕和终止中期妊娠的作用。抗孕-53对家兔抗着床时,血浆孕酮和雌激素变化不显著;抗孕-53对早孕家兔血浆孕酮水平明显下降,但对血浆雌激素水平无影响。
The rabbits were drenched with anti-pregnancy -53 (10.5mg / kg) on the 1st day and the laparotomy on the 11th day. The number of implantation in the control group was 9.7 ± 1.6 (mean ± SEM), the experimental group was 0.4 ± 0.4; Pregnant -53 (5mg / kg / day) was administered continuously on the 7th to 9th days and the necropsy was performed on the 17th day. The number of live fetuses in the control group was 7.5 ± 1.1, the number of live fetuses in the experimental group was 0.3 ± 0.3 and the number of stillbirths was 7.0 ± 0.5 On the 22nd day of pregnancy, one injection of anti-pregnancy -53 (1.25mg / kg) was injected intramuscularly on the 22nd day of pregnancy. The number of alive fetuses was 12.2 ± 0.2 in the control group and 11.9 ± 0.5 in the experimental group. That anti-pregnancy -53 significant anti-implantation, anti-early pregnancy and termination of the role of medium-term pregnancy. Anti-pregnancy -53 pairs of rabbits anti-implantation, the plasma progesterone and estrogen did not change significantly; anti-pregnancy -53 pairs of early pregnancy plasma progesterone levels were significantly reduced, but no effect on plasma estrogen levels.