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临床上酒精诱发的股骨头缺血性坏死常见[1]。动物实验证明酒精可导致股骨头骨髓内脂肪细胞增殖肥大,骨细胞脂肪变性、坏死[2]。但其机制尚不完全清楚,本研究采用细胞体外培养,观察酒精对小鼠骨髓基质细胞(marrowstromalcells,MSCs)的影响,探讨骨坏死时骨髓内脂肪增多的原因,进
Clinically induced alcohol-induced avascular necrosis of the femoral head is common [1]. Animal experiments show that alcohol can lead to femoral head bone marrow adipocyte hypertrophy, osteogenic steatosis, necrosis [2]. However, its mechanism is not yet fully understood. In this study, the effects of alcohol on marrow stromal cells (MSCs) in mice were observed by using cultured cells in vitro to investigate the reasons for increased bone marrow fat in osteonecrosis