Characteristics of peripheral nerve collateral multiplication and its potential use in neural trauma

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To the editor:It is well known that outgrowth of collateral sprouts is a natural process during regeneration of the peripheral nervous system.However,current knowledge about this phenomenon was that aberrant growth of axonal sprouts may lead to the formation of persistent neuromas.1,2 From our previous work3-5 verified effectively in clinical environment for nerve repairing and related experiments by small gap sleeve neurorrhaphy,we made a possible inference for peripheral nerve collateral regeneration and functional repairing;the hypothesis of using these collateral sprouts as an auto graft resource to recover the injured nerve.This study focuses on the multiplication limit of the collaterals that could be maintained during peripheral nerve regeneration,and the possibility of using partial axons from an intact nerve to repair a nearby nerve with little influence on the donor nerve disfunction.
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