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目的:探讨吗啡、氯胺酮联合应用在癌痛治疗中的疗效。方法:43例晚期癌痛患者随机分为观察组(n=22例)和观察组(n=21例)。给予对照组吗啡治疗,给予观察组吗啡、氯胺酮联合治疗,对比两组疗效。结果:两组治疗前、治疗30min、治疗1h、治疗5h、治疗24h以及治疗48h的疼痛评分相比,均无统计学差异(P>0.05)。观察组吗啡用量以及便秘、恶心呕吐、皮肤瘙痒等不良反应明显地低于对照组(P<0.05)。结论:吗啡、氯胺酮联合用药在癌痛治疗中的镇痛效果佳,应广泛推广应用。
Objective: To investigate the curative effect of combination of morphine and ketamine in the treatment of cancer pain. Methods: Forty-three patients with advanced cancer pain were randomly divided into observation group (n = 22) and observation group (n = 21). Morphine treatment was given to the control group, morphine and ketamine were given to the observation group, and the curative effect was compared between the two groups. Results: There was no significant difference in the pain scores of two groups before treatment, 30 minutes of treatment, 1 hour of treatment, 5 hours of treatment, 24 hours of treatment and 48 hours of treatment (P> 0.05). Morphine dosage and constipation, nausea and vomiting, pruritus and other adverse reactions in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: The combination of morphine and ketamine has a good analgesic effect in the treatment of cancer pain and should be widely applied.