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目的:了解我院药品不良反应(ADR)发生的特点,为临床合理用药提供参考。方法:对我院2013年收集上报的有效ADR报告322例按患者性别、年龄、给药途径、药物种类、ADR累及器官和系统、临床表现、转归、上报人职业等进行统计、分析。结果:322例ADR中,男174例,女148例,男女比例1.18∶1;静脉滴注为ADR发生的主要途径(90.96%),其次为口服给药(4.66%);上报人群以医生为主,共191例(59.32%),其次护士122例(37.89%);以药物种类计抗感染药物致ADR最多,共132例(36.16%),其次是抗病毒药34例(9.32%);ADR临床表现以皮肤及其附件损害最多,共170例(40.48%)。结论:应重视ADR的监测和宣传工作,降低ADR的发生率,促进临床合理用药,保障患者用药安全。
Objective: To understand the characteristics of adverse drug reaction (ADR) in our hospital and provide a reference for clinical rational drug use. Methods: 322 cases of ADR reported in our hospital in 2013 were statistically analyzed according to the patient’s sex, age, route of administration, drug type, organs and systems involved in ADR, clinical manifestations, outcome and occupational reporting. Results: Among 322 ADRs, 174 were males and 148 were females, the ratio of male to female was 1.18:1. Intravenous instillation was the main route of ADR (90.96%), followed by oral administration (4.66%). The total number of ADRs was 132 (36.16%), followed by 34 (9.32%) of antiviral drugs. The number of ADRs was the highest in 191 (59.32%) patients, followed by 122 nurses (37.89%). ADR clinical manifestations of the skin and its accessories damage the most, a total of 170 cases (40.48%). Conclusion: We should pay attention to the monitoring and publicity of ADR, reduce the incidence of ADR, promote the rational use of clinical medicine and ensure the safety of patients.