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目的:观察注射用丹参多酚酸盐治疗冠心病心绞痛合并2型糖尿病的疗效。方法:将120例冠心病心绞痛合并2型糖尿病患者随机分为治疗组、对照组两组,每组各60例,两组患者均给予常规药物,如抗血小板、调脂、ACEI、β受体阻滞剂、降糖药物等。治疗组注射用丹参多酚酸盐(上海绿谷制药有限公司生产)200 mg加入5%葡萄糖注射液或0.9%氯化钠注射液250 m L/d静滴。两组连续治疗10 d为1个疗程,治疗1个疗程。评价两组的心绞痛疗效和心电图,观察两组治疗前后的硝酸甘油减停数和血糖指标改变情况。结果:1心绞痛疗效:治疗组的总有效率为85.0%,显著高于对照组的60.0%(P<0.05)。2心电图评价:治疗组缺血改善率为70.0%,对照组为60.0%,差异有统计学意义(P<0.05)。3硝酸甘油停减数:治疗后两组的硝酸甘油停减数较治疗前均显著改善(P<0.05)。4糖尿病指标:治疗后两组糖尿病指标较治疗前均有明显改善,与治疗前比较差异有统计学意义(P<0.05)。结论:注射用丹参多酚酸盐明显改善冠心病心绞痛合并2型糖尿病患者的临床症状、心电图及糖尿病相关临床指标,减少硝酸甘油用量,且安全性良好,是治疗冠心病心绞痛合并2型糖尿病安全而有效的药物。
Objective: To observe the efficacy of Salviae miltiorrhizae polyphenols for the treatment of type 2 diabetes mellitus with angina pectoris. Methods: 120 patients with angina pectoris and type 2 diabetes mellitus were randomly divided into treatment group and control group, 60 cases in each group. Both groups were given conventional drugs such as antiplatelet, lipid-lowering, ACEI, β receptor Blockers, hypoglycemic drugs. The treatment group was injected with Salviae miltiorrhizinate polyphenols (Shanghai Lvgu Pharmaceutical Co., Ltd.) 200 mg injection of 5% glucose injection or 0.9% sodium chloride injection 250 m L / d intravenous infusion. Two consecutive treatment of 10 d for a course of treatment for a course of treatment. The angina pectoris and electrocardiogram were evaluated in both groups, and the reduction of nitroglycerin and the change of glycemic index before and after treatment were observed. Results: 1 angina curative effect: The total effective rate of the treatment group was 85.0%, significantly higher than 60.0% of the control group (P <0.05). 2 ECG evaluation: The treatment group, ischemic improvement rate was 70.0%, 60.0% in the control group, the difference was statistically significant (P <0.05). 3 Nitroglycerin stop: After treatment, the number of nitroglycerin in both groups than before treatment were significantly improved (P <0.05). 4 Diabetes mellitus indicators: After treatment, the indexes of both groups of diabetes mellitus were significantly improved compared with that before treatment, with statistical significance (P <0.05). Conclusion: Salviae miltiorrhizae polyphenols can significantly improve the clinical symptoms, electrocardiogram and diabetes-related clinical indexes, reduce the dosage of nitroglycerin in patients with type 2 diabetes mellitus and coronary heart disease angina pectoris, and have good safety. It is a safe and safe method for the treatment of type 2 diabetes mellitus And effective medicine.