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目的探讨原发性高血压（ＥＨ）患者运动前后血压、心率的变化，以及心功能和房促尿钠多肽（ＡＮＰ）变化的相互关系及临床意义。方法１２１例ＥＨ患者和４１例血压正常值者进行组间血压心率比较和用多元线性回归分析法评价两组运动前后心功能与ＡＮＰ之间的相互关系。结果运动可使ＥＨ患者心功能得到一定改善，血清ＡＮＰ含量可反应心脏舒张功能储备损害和左心室顺应性损害的程度。结论 ＥＨ患者适当运动有益于降低血压和改善心功能。
Objective To investigate the changes of blood pressure and heart rate before and after exercise in patients with essential hypertension (EH) and the relationship between cardiac function and atrial natriuretic peptide (ANP) and its clinical significance. Methods 121 cases of EH patients and 41 cases of normotensive patients were compared between groups of blood pressure and heart rate and multivariate linear regression analysis of the two groups before and after exercise to assess the relationship between heart function and ANP. Results Exercise can improve cardiac function in patients with EH, serum ANP content can reflect the impairment of left ventricular diastolic function reserve damage and degree of left ventricular compliance. Conclusion EH patients with appropriate exercise beneficial to lower blood pressure and improve cardiac function.