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目的:探讨氯吡格雷(泰嘉)治疗不稳定型心绞痛(unstable angina pectoris,UAP)的疗效。方法:102例不稳定型心绞痛患者随机分治疗组(60例)和对照组(42例),治疗组在常规药物的基础上加氯吡格雷50mg,每天1次,连用4周。对照组用常规药物治疗。两组均观察心绞痛的发作次数、24h动态心电图。结果:治疗组显效43例(79.6%),有效5例(9.3%),对照组显效23例(48.0%),有效10例(20.8%),两组相比差异有显著性(p<0.05)。治疗组心绞痛的发作次数与对照组比较明显减少(P<0.01)、24h动态心电图与对照组比较明显改善(P<0.01)。结论:UAP患者在常规药物治疗的基础上联用低剂量氯吡格雷可取得良好效果,且安全性好。
Objective: To investigate the efficacy of clopidogrel in the treatment of unstable angina pectoris (UAP). Methods: A total of 102 patients with unstable angina pectoris were randomly divided into treatment group (n = 60) and control group (n = 42). The treatment group was given clopidogrel 50 mg once daily for 4 weeks on the basis of conventional drugs. Control group with conventional drug treatment. The incidence of angina pectoris was observed in both groups, 24h dynamic electrocardiogram. Results: There were 43 cases (79.6%) in treatment group and 5 cases (9.3%) in effective group, 23 cases (48.0%) in control group and 10.8% (20.8%) in control group ). The frequency of angina pectoris in the treatment group was significantly decreased compared with that in the control group (P <0.01), and the 24h dynamic electrocardiogram was significantly improved compared with the control group (P <0.01). Conclusion: UAP patients with low-dose clopidogrel combined with conventional drug therapy can achieve good results and good safety.