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目的探讨丁苯酞软胶囊联合氯吡格雷治疗急性分水岭脑梗死的临床疗效。方法收集急性分水岭脑梗死患者314例,按照纳入标准及患者知情同意选取202例,分为对照组(98例)和丁苯酞组(104例)。对照组给予常规治疗及氯吡格雷片75mg,口服,1次/晚,抗血小板聚集,丁苯酞组在上述治疗基础上加用丁苯酞软胶囊,0.2g/次,3次/d,疗程为12d。采用NIHSS评分与BI评分评价治疗前,治疗后第十二天二组的神经功能与日常生活能力。结果治疗后二组的NIHSS评分显著降低,BI评分显著增高(P<0.05)。丁苯酞组在治疗后第十二天的NIHSS评分明显低于治疗前及对照组,差异均具有统计学意义(P<0.05),在治疗后第十二天的BI评分则明显高于治疗前及对照组,差异均具有统计学意义(P<0.05)。结论丁苯酞软胶囊联合氯吡格雷治疗急性分水岭脑梗死具有较好的临床疗效。
Objective To investigate the clinical efficacy of butylphthalide soft capsule combined with clopidogrel in the treatment of acute watershed cerebral infarction. Methods A total of 314 patients with acute watershed cerebral infarction were collected and divided into control group (n = 98) and butylphthalide group (n = 104) according to the inclusion criteria and informed consent of patients. Control group was given routine treatment and clopidogrel 75mg, oral, 1 / night, anti-platelet aggregation, butylphthalide group based on the above treatment with butylphthalide soft capsule, 0.2g / time, 3 times / d, Treatment for 12d. NIHSS score and BI score were used to evaluate the neurological function and daily living ability of the two groups before treatment and 12 days after treatment. Results After treatment, the NIHSS scores of the two groups were significantly lower and the BI scores were significantly higher (P <0.05). Butylphthalide group NIHSS score on the 12th day after treatment was significantly lower than before treatment and control group, the difference was statistically significant (P <0.05), after 12 days of treatment BI score was significantly higher than the treatment Before and in the control group, the differences were statistically significant (P <0.05). Conclusion Butylphthalide soft capsule combined with clopidogrel in the treatment of acute watershed cerebral infarction has a good clinical effect.