Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four Sprague-Dawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong (equivalent to ST40 in humans) on the hind legs were covered with a placebo (general mucilage) for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices (HSIs) and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol (TC),glycerinate,lowdensity lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDL-C,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSls appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.