应用胸苷同步化方法,对比分析了染色体凝缩抑制剂溴化乙锭及放线菌素D对高分辨染色体的影响。结果表明,溴化乙锭组高分辨分裂细胞比例高,染色体带纹稳定,染色体断裂率低。放线菌素D组染色体带纹出现不均匀凝缩现象,染色体断裂率增高。提示溴化乙锭是一种稳定的染色体凝缩抑制剂,优于放线菌素D。 Using thymidine synchronization method, the effects of chromosomal condensation inhibitor ethidium bromide and actinomycin D on high-resolution chromosomes were compared. The results showed that the proportion of high-resolution dividing cells in the ethidium bromide group was high, the chromosome stripe was stable, and the chromosome breakage rate was low. In the actinomycin D group, uneven condensing occurred in the chromosomal band, and the chromosome breakage rate increased. It is suggested that ethidium bromide is a stable chromosomal condensation inhibitor that is superior to actinomycin D.