论文部分内容阅读
早在1964年,人们就将以硅酮为材料的植入剂埋于体内做为控释给药系统。尽管剂型安全有效,易于接受,但至今进展缓慢。植入给药对各种药物,尤其是对不能口服的药物是非常合适的,同时,此剂型药物的治疗指数也相应提高。传统的给药系统,如栓剂、滴眼剂、乳剂、吸入气雾剂、注射剂等,常因血药浓度的波动产生副作用。植入控释给药系统
As early as 1964, silicone implants were buried in the body as a controlled release drug delivery system. Although safe, effective, and acceptable, the dosage form has been slow to date. Implants are well suited for a variety of drugs, especially those that can not be taken orally, and the therapeutic index for this dosage form is also increased accordingly. Traditional delivery systems, such as suppositories, eye drops, creams, inhalation aerosols, injections and the like, often have side effects due to fluctuations in plasma concentration. Implanted controlled release drug delivery system