【摘 要】
:
Intracranial germinomas are malignant neoplasms of gonadal origin,which have some features in terms of age,sex,and clinical manifestations.They mainly occur in
【机 构】
:
Zhongshan Ophthalmic Center,Department of Ophthalmology
【基金项目】
:
广东省自然科学基金;The Fundamental Research Funds of State Key Laboratory of Ophthalmology;国家自然科学基金
论文部分内容阅读
Intracranial germinomas are malignant neoplasms of gonadal origin,which have some features in terms of age,sex,and clinical manifestations.They mainly occur in children and adolescents.Patients with intracranial germinomas mainly manifest with hypothalamic pituitary axis dysfunction and/or compression syndromes.Visual disturbance is one of the most significant clinical presentations.which is mainly caused by tumor cell infiltration into the optic pathway.In this article,we present three cases of patient with intracranial germinoma to analyze the ocular manifestations.All the three patients presented with endocrine symptoms in the early stage and with visual disturbances (including decreased visual acuity and visual field defects) later.In general,germinoma is diagnosed by its characteristic radiological appearance,supported by tumor markers and/or stereotactic biopsy.However,decisive diagnoses were established when ocular manifestations were presented.A suspicion for germinoma should be considered,when young patients manifest visual disturbances accompanied by endocrine symptoms.
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