目的探讨自拟培肾汤重用黄芪治疗局灶节段硬化性肾小球肾炎(FSGS)的疗效。方法选择100例FSGS患者,按照数字列表法随机分为对照组与治疗组各50例,对照组采用常规激素、免疫抑制剂治疗。治疗组在对照组治疗基础上加用自拟培肾汤,2组均以3个月为1个疗程,4个疗程结束后,比较2组治疗疗效。结果观察组痊愈率为72%,对照组为62%,2组比较差异有统计学意义(P<0.05);观察组治疗3个月、12个月24h UPro及血SCr、BUN、UA水平低于对照组,ALB水平高于对照组,2组比较差异均有统计学意义(P均<0.05);观察组复发率为5%,对照组为13%,2组比较差异有统计学意义(P<0.05)。结论自拟培肾汤重用黄芪可有效缓解FSGS患者临床症状,降低复发率。 Objective To investigate the curative effect of self-made Peizhuyin Decoction with Astragalus in the treatment of focal segmental glomerulonephritis (FSGS). Methods 100 patients with FSGS were selected and randomly divided into control group and treatment group according to the digital list method, 50 cases in each group. The control group was treated with conventional hormones and immunosuppressive agents. Treatment group in the control group based on the addition of self-Peizhen Decoction, two groups were 3 months for a course of treatment, after the end of 4 courses, the treatment effect of two groups were compared. Results The cure rate was 72% in the observation group and 62% in the control group. There was significant difference between the two groups (P <0.05). The levels of UPro and SCr, BUN and UA in the observation group were significantly lower at 3 months and 12 months In the control group, the level of ALB was higher in the control group than in the control group (P <0.05). The recurrence rate was 5% in the observation group and 13% in the control group. There was significant difference between the two groups P <0.05). Conclusion Self-made Peizhu Decoction reuse Astragalus can effectively alleviate the clinical symptoms of FSGS patients and reduce the recurrence rate.