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目的:探讨轮状病毒(RV)感染肠道外脏器受损的相关因素、临床表现特点及预后。方法:将2007年10月～2009年1月在本院住院的轮状病毒(RV)肠炎患儿325例,按其肠外脏器受损的有无分为观察组与对照组,比较2组的一般情况、肠道症状、肠外表现、实验室资料及预后。结果:55.3%的RV肠炎合并肠外脏器受损,心肌、呼吸道、肝脏、中枢神经、血液系统受累,有1个、2个、3个脏器同时受累。≤6个月小儿最易有肠外表现,发热、脱水、酸中毒、C-反应蛋白升高亦与肠外表现相关,但肠外脏器受累预后较好,心肌酶、肝酶、CRP1周内基本恢复正常,仅少数2周左右恢复。结论:RV是一种能引起全身脏器损害的疾病,在诊治RV肠炎患儿时,应重视肠外脏器受损情况,予以及时有效处理。
Objective: To investigate the related factors, clinical manifestations and prognosis of intestinal damage caused by rotavirus (RV) infection. Methods: 325 patients with rotavirus (RV) enteritis hospitalized in our hospital from October 2007 to January 2009 were divided into observation group and control group according to the presence or absence of extraintestinal organ damage, compared with 2 General conditions of the group, intestinal symptoms, extraintestinal manifestations, laboratory data and prognosis. Results: 55.3% of RV enteritis was associated with impaired parenteral organs. Myocardial, respiratory, hepatic, central nervous and blood systems were affected. One, two and three organs were affected simultaneously. ≤ 6 months in children with the most vulnerable to parenteral manifestations, fever, dehydration, acidosis, elevated C-reactive protein is also associated with parenteral manifestations, but the prognosis of intestinal extraintestinal involvement is better, myocardial enzymes, liver enzymes, CRP1 weeks Within the basic return to normal, only a few weeks to recover. Conclusion: RV is a disease that can cause damage to the whole body organs. In the diagnosis and treatment of children with RV enteritis, the damage of parenteral organs should be emphasized and promptly and effectively treated.