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介绍生理药代动力学(PBPK)模型的特征及其研究现状。通过Pubmed检索工具,查询国内外相关文献21篇,对PBPK模型的构建、模型特征和应用现状进行了文献整理和分析。目前PBPK模型已经广泛应用于有毒化合物的安全性评价、药物代谢过程研究、代谢酶和转运蛋白对药物代谢的影响、药物-药物相互作用以及新药的研发过程等研究之中。尽管PBPK模型有很多优势,获得了令人鼓舞的评价结果,但其构建需要数学和计算机的支持以及系统生物学、药物化学、药理学和数学、统计学等多学科专业人员合作,做进一步的探索和完善。
The characteristics of physiological pharmacokinetics (PBPK) model and its research status are introduced. Through the Pubmed search tool, 21 references were collected from domestic and foreign literature, and the literature review of the PBPK model construction, model features and application status were carried out. At present, the PBPK model has been widely used in the safety evaluation of toxic compounds, drug metabolism process, metabolic enzymes and transporters on drug metabolism, drug-drug interactions and new drug research process. Although the PBPK model has many advantages and encouraging results, its construction requires the support of mathematics and computers as well as multidisciplinary professionals such as systems biology, medicinal chemistry, pharmacology and mathematics, statistics, and further Explore and improve.