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目的研究阿霉素溶液和阿霉素纳米粒体外释放行为的不同。方法:采用零级动力学方程、一级动力学方程、Higuchi方程和双相动力学方程拟合药物在体外的释放行为,根据拟合优度来判定曲线拟合情况,探讨方程所反应的释放机理。结果:阿霉素溶液在生理盐水中的体外释药用零级动力学方程、Higuchi方程和双相动力学方程拟合,拟合优度均不很好,而一级动力学方程则比较好。阿霉素溶液在体外的释放较快;阿霉素纳米粒在生理盐水中的释药情况用零级动力学方程、一级动力学方程和Higuchi方程描述时,拟合优度均不很好,而双相动力学方程则较好。阿霉素纳米粒在体外的释放较为缓慢。结论:阿霉素溶液体外释放速度较快,符合一级动力学方程;阿霉素纳米粒在体外的释放符合双相动力学方程。纳米粒在释药前由于纳米粒表面吸附有阿霉素,所以释药快,后来因为载体材料的溶解逐渐将阿霉素释放出来,这种释药规律符合抗癌药物的用药原则。
Objective To study the different release behavior of doxorubicin and doxorubicin nanoparticles in vitro. Methods: The zero-order kinetic equation, first-order kinetic equation, Higuchi equation and biphase dynamic equation were used to fit the drug release behavior in vitro. The curve fitting was judged according to the goodness of fit and the release of the reaction mechanism. Results: In vitro release of doxorubicin solution in normal saline was fitted with zero-order kinetic equation, Higuchi equation and biphase kinetic equation, and the goodness of fit was not good, while the first-order kinetic equation was better . Doxorubicin release faster in vitro; doxorubicin nanoparticles release in normal saline with zero-order kinetic equation, first-order kinetic equation and Higuchi equation described goodness of fit are not good , While the two-phase kinetic equation is better. Adriamycin nanoparticles release more slowly in vitro. Conclusion: The doxorubicin solution release faster in vitro, in line with the first-order kinetic equation; release of doxorubicin nanoparticles in vitro in line with the biphasic kinetic equation. Since nanoparticles adsorbed doxorubicin on the surface of nanoparticles prior to drug release, the drug release was fast and later the doxorubicin was released gradually due to the dissolution of the carrier material. The drug release pattern was in line with the principle of anticancer drug administration.