小诺霉素(Micronomicin,MCR)是一种氨基糖苷类抗生素,临床试验证明其针剂对治疗细菌性感染有明显疗效,抗革蓝氏阴性菌感染显效率可达79.8％,优于庆大霉素(GM),特别是对肠道感染疗效更为明显。据此无锡第四制药厂研制了硫酸小诺霉素片剂。本文报道硫酸小诺霉素片剂与庆大霉素片剂一样,口服后在小鼠肠道内具有抗痢疾杆菌的效果。体外试验证明对耐氯霉素伤寒杆菌、空肠弯曲菌、结肠弯曲菌有明显的抑 Micronomicin (MCR), an aminoglycoside antibiotic, has been clinically proven to be effective in the treatment of bacterial infections. The effective rate against gram-negative bacteria was 79.8%, which was better than that of Gentamicin (GM), especially for the treatment of intestinal infections more obvious. Accordingly, Wuxi No.4 Pharmaceutical Factory has developed a tablet of microtomycin sulfate. This article reports that trnovan sulfate tablets, like gentamicin tablets, have an anti-dysentery bacillus effect in the gut of mice after oral administration. In vitro tests show that the resistance to chloramphenicol Salmonella typhi, Campylobacter jejuni, Campylobacter coli obvious inhibition