牙周炎和糖尿病都是严重危害人类健康的常见病和高发病。有大量的研究证实,牙周炎和糖尿病是一种相互影响的双向关系[1]。因此,口腔医生必须重视对糖尿病患者牙周炎的防治。日本新时代株式会社生产的盐酸二甲胺四环素软膏(派丽奥),是口腔科常用局部治疗牙周炎药物[2]。我们从2008年1月起将其用于治疗糖尿病所致的 Periodontitis and diabetes are both common and high-risk diseases that seriously endanger human health. A large number of studies have confirmed that periodontitis and diabetes are an interactive two-way relationship [1]. Therefore, the dentist must pay attention to prevention and treatment of periodontitis in diabetic patients. Japan New Era Co., Ltd. production of minocycline hydrochloride ointment (Palio), is commonly used in dental stomatitis periodontitis drugs [2]. We have been using it for the treatment of diabetes since January 2008