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目的观察利福平注射液治疗初治涂阳肺结核的强化期疗效及不良反应。方法 42例痰涂抗酸杆菌阳性肺结核患者随机分为治疗组(n=20)和对照组(n=22),治疗组给予国产利福平注射液,联合其他3种抗结核药物;对照组给予利福平胶囊,联合其他3种抗结核药物。治疗2个月后观察疗效与不良反应。结果治疗2个月末胸片病灶吸收率治疗组为85.0%,对照组为81.8%,差异无统计学意义(P>0.05)。治疗组不良反应3例(15%),对照组6例(27.3%),差异有统计学意义(P<0.05)。结论利福平注射液在肺结核的治疗中具有局部药物浓度高,作用快,不良反应小的特点。
Objective To observe the effects and adverse reactions of rifampin injection in the treatment of newly diagnosed smear positive pulmonary tuberculosis. Methods 42 cases of sputum acid-fast bacilli positive pulmonary tuberculosis patients were randomly divided into treatment group (n = 20) and control group (n = 22). The treatment group was given domestic rifampicin injection combined with the other three kinds of anti-tuberculosis drugs. Rifampicin capsules, combined with the other three kinds of anti-TB drugs. After 2 months of treatment efficacy and adverse reactions were observed. Results At the end of 2 months, the absorptive rate of the chest radiograph was 85.0% in the treatment group and 81.8% in the control group, with no significant difference (P> 0.05). There were 3 adverse reactions (15%) in treatment group and 6 cases (27.3%) in control group, the difference was statistically significant (P <0.05). Conclusions Rifampicin injection has the characteristics of high concentration of local drug, rapid action and small adverse reaction in the treatment of pulmonary tuberculosis.