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目的:探讨提高孕7-9周药物流产的有效性药物剂量。方法:因非意愿妊娠要求终止早孕的孕7-9周妇女256例,随机分为二组,A组(109例)和B组(147例)。d1-2分别分次口服米非司酮150mg或200mg;d3口服米索前列醇600μg,4h后无论胚囊是否排出,均加服米索400μg。结果:A组完全流产率为91.2%,B组为92.5%,P>0.05。药物流产后阴道出血时间、出血量、转经时间、经期及经量二组均无统计学差异。结论:两种方法的完全流产率均达到90%以上,200mg米非司酮配伍米索前列醇,可能减少孕囊排出时的出血量,对孕7-9周的妇女不失为一种安全的药物流产手段。
Objective: To explore the effective drug dose to improve the medical abortion of 7-9 weeks pregnant. Methods: Two hundred and sixty-six women aged 7-9 weeks who were asked to terminate early pregnancy because of unwanted pregnancy were randomly divided into two groups: group A (109 cases) and group B (147 cases). d1-2 were given oral mifepristone 150mg or 200mg; d3 oral misoprostol 600μg, 4h regardless of whether the embryo sac is excreted, add 400ml misoprostol. Results: The complete abortion rate was 91.2% in group A and 92.5% in group B, P> 0.05. After medical abortion vaginal bleeding time, bleeding volume, menstrual cycle time, menstrual flow and the amount of no significant difference between the two groups. CONCLUSIONS: The complete abortion rates of both methods are above 90%. The combination of 200 mg mifepristone and misoprostol may reduce the amount of bleeding during the gestational sac excretion, which is a safe drug for pregnant women aged 7-9 weeks Abortion means.