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AnnexinⅡ是一种钙依赖性磷脂结合蛋白,有一个短的决定其生物学特性的疏水N-端结构域和一个参与磷脂结合的核心区。AnnexinⅡ参与了多种生物学活动,包括信号转导、细胞迁移、DNA合成、细胞增殖和凋亡等。近来多项研究表明,AnnexinⅡ在多种肿瘤中表达失调,且其表达水平和肿瘤的发生、浸润、转移、临床分期和愈后密切相关。仅就AnnexinⅡ的生物学特点及其与肿瘤的关系研究进行综述。
Annexin II is a calcium-dependent phospholipid-binding protein with a short hydrophobic N-terminal domain that determines its biological properties and a core region involved in phospholipid binding. Annexin II is involved in a variety of biological activities including signal transduction, cell migration, DNA synthesis, cell proliferation and apoptosis. Recently a number of studies have shown that Annexin Ⅱ in a variety of tumor expression disorders, and its expression level and tumor occurrence, invasion, metastasis, clinical stage and prognosis are closely related. Only the biological characteristics of Annexin Ⅱ and its relationship with the tumor were reviewed.