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某些危重疾病的发生、发展与自由基有重要关系,特别是与氧自由基的作用更为密切。本文报道内科危重病患者氧自由基的变化。对86例危重病,包括冠心心梗组35例,风心心衰组12例,脑梗塞组9例,慢肾衰组22例,急肾衰组8例。入院时测定SOD/MDA含量,结果表明,各病例组均显示MDA升高,与正常对照组比有显著差异(P<0.05～0.001)。冠心、心梗、风心、心衰SOD有降低,统计学无显著差异(P>0.05),脑梗塞和慢肾衰患者SOD活力有升高(P<0.05),可能由于MDA升高,引起全血自由基清除剂SOD代偿升高。对23例冠心心梗患者。经用自制中药(生脉、丹参、当归注射液)静脉给药后3～7天复查。测定SOD/MDA含量,结果SOD活力升高,与治疗前比有显著差异(P<0.001);MDA含量降低,无显著差异(P>0.05)。表明,中药(生脉、丹参、当归注射液)静脉给药对氧自由基变化有影响,值得继续研究探讨。
The occurrence and development of some critical diseases have an important relationship with free radicals, especially with oxygen free radicals. This article reports the changes of oxygen free radicals in critical medical patients. Of the 86 critically ill patients, 35 were in the group of coronary heart disease, 12 in the heart failure group, 9 in the cerebral infarction group, 22 in the chronic renal failure group and 8 in the acute renal failure group. The level of SOD / MDA was measured at admission. The results showed that all the cases showed elevated MDA, which was significantly different from the normal control group (P <0.05 ~ 0.001). (P <0.05). SOD activity in cerebral infarction and chronic renal failure patients was increased (P <0.05), which may be due to the increase of MDA, Caused by the whole blood free radical scavenger SOD compensatory increase. 23 cases of patients with coronary heart disease. With homemade medicine (Shengmai, Salvia, Angelica injection) intravenous 3 to 7 days after the review. The content of SOD / MDA was measured. The results showed that the activity of SOD increased significantly compared with that before treatment (P <0.001). The content of MDA decreased but had no significant difference (P> 0.05). Show that the traditional Chinese medicine (Shengmai, Salvia, Angelica injection) intravenous administration of oxygen free radicals change, it is worth continuing research.