近年来随着造血干细胞保存技术的进步,临床应用自身骨髓移植已成为可能。很多作者报道移植自身骨髓可以加速骨髓重建,减少感染和出血,避免造血干细胞的严重抑制,并使病情获得缓解。1983年12月中旬我们对一例晚期恶性淋巴瘤采用单次大剂量放疗、化疗并用自身骨髓移植取得较好的效果,现介绍如下,并作初步探讨。材料与结果赵××,男性,31岁。颈部肿块进行性增大7个月,腹部隐痛4个月。入院检查发现鼻咽腔、双颈、回肠末端和腹膜后淋巴结为肿瘤所侵。鼻咽及右颈淋巴结活检证实为恶性淋巴瘤组织细胞型。临床诊断恶性淋巴瘤Ⅳ期。治疗经过:病人收入水平层流生物洁净病室,一切皆按无菌隔离要求。给予口服黄 In recent years, with the advancement of hematopoietic stem cell preservation technology, clinical application of its own bone marrow transplantation has become possible. Many authors report that transplanting their own bone marrow can accelerate bone marrow reconstitution, reduce infection and bleeding, to avoid severe inhibition of hematopoietic stem cells, and make the condition eased. In mid-December 1983, we performed a single high-dose radiotherapy and chemotherapy on one case of advanced malignant lymphoma and achieved good results with our own bone marrow transplantation. We will introduce the following and make preliminary discussions. Materials and Results Zhao XX, male, 31 years old. Progressive neck mass 7 months, abdominal pain for 4 months. Admission examination found that the nasopharynx, neck, ileum and retroperitoneal lymph nodes invading the tumor. Nasopharyngeal and right cervical lymph node biopsy confirmed malignant lymphoma tissue cell type. Clinical diagnosis of malignant lymphoma stage Ⅳ. After treatment: the level of patient income laminar flow of clean living room, everything according to aseptic isolation requirements. Give oral yellow