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目的观察门冬氨酸鸟氨酸联合乳果糖治疗酒精性肝病高氨血症的临床疗效。方法随机将54例酒精性肝病高血氨患者分成三组,A组18例静脉点滴门冬氨酸鸟氨酸联合白醋灌肠,B组18例静脉点滴门冬氨酸鸟氨酸,C组18例给予门冬氨酸鸟氨酸联合乳果糖灌肠,观察治疗后7、14、21、28 d患者血氨、肝功能的变化。结果治疗后三组患者血氨、肝功能水平均较治疗前明显好转,但C组与A、B组组间比较差异有统计学意义(P<0.05),A、B两组间比较差异无统计学意义(P>0.05)。结论门冬氨酸鸟氨酸联合乳果糖灌肠治疗高氨血症优于单用门冬氨酸鸟氨酸或门冬氨酸鸟氨酸联合白醋灌肠,且效果明显,安全、有效,值得临床推广应用。
Objective To observe the clinical efficacy of ornithine aspartate combined with lactulose in the treatment of alcoholic liver disease with hyperammonemia. Methods A total of 54 patients with alcoholic liver disease and hypernatremia were randomly divided into three groups. Group A received either aspartic acid ornithine plus white vinegar enema in 18 patients, group B received intravenous ornithine aspartate in 18 patients, and group C received 18 Cases given aspartic acid ornithine combined lactulose enema, observed after treatment, 7,14,21,28 d patients with changes in serum ammonia, liver function. Results After treatment, the levels of serum ammonia and liver function in the three groups were significantly improved compared with those before treatment, but there was significant difference between group C and groups A and B (P <0.05). There was no significant difference between groups A and B Statistical significance (P> 0.05). Conclusions Aspartate ornithine combined with lactulose enema is superior to ornithine aspartate or aspartate or white vinegar enema in the treatment of hyperammonemia, which is effective and safe Promote the application.