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目的探讨PCNA、P~(21)的表达与喉非典型增生的预后是否相关。方法用免疫组化ABC法对63例喉非典型增生(其中4O例转化为癌,另23例未转化)、56例喉鳞癌和7例正常喉组织进行了PCNA、P~(21)检测。结果 PCNA指数和P~(21)阳性率在非典型增生转化组与癌间、未转化组与癌间差别均有统计意义(p<0.01),在非典型增生转化组与未转化组之间差别无统升意义。结论 PCNA对衡量喉非典型增生及喉癌的细胞增殖状态有一定的价值,P~(21)与喉癌的发生机制有关,但两者的表达均与喉非典型增生的预后无明显关系。
Objective To investigate the relationship between the expression of PCNA, P ~ (21) and the prognosis of laryngeal atypical hyperplasia. Methods Immunohistochemical ABC method was used to detect PCNA, P ~ (21) in 63 cases of laryngeal atypical hyperplasia (40 cases converted into carcinoma and 23 cases untransformed), 56 cases of laryngeal squamous cell carcinoma and 7 cases of normal laryngeal tissue. . Results The PCNA index and the positive rate of P ~ (21) in the atypical hyperplastic transformation group and the non-transformed group were significantly different from those in the non-transformed group and the non-transformed group (p <0.01) There is no difference between the meaning of unification. Conclusions PCNA is of value in measuring the proliferation of laryngeal carcinoma and atypical hyperplasia of the larynx. P ~ (21) is related to the pathogenesis of laryngeal carcinoma, but both of them are not related to the prognosis of laryngeal atypical hyperplasia.