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目的研究布地奈德雾化吸入与固尔苏配合鼻塞持续气道正压通气防治新生儿呼吸窘迫综合征(ARDS)的临床疗效。方法 20例新生儿呼吸窘迫综合征患儿,按照数字随机法分为研究组与对照组,每组10例。对照组给予固尔苏混合液气管内滴入配合鼻塞持续气道正压通气治疗,研究组在此基础上给予布地奈德雾化吸入治疗。观察两组患儿治疗前后血气分析结果、固尔苏重复使用情况及并发肺炎情况。结果治疗后1、6 h研究组各项指标均显著优于对照组,差异具有统计学意义(P<0.05);研究组痊愈病例显著多于对照组(P<0.05);机械通气、肺部感染及重复使用固尔苏病例显著少于对照组(P<0.05)。结论布地奈德雾化吸入与固尔苏配合鼻塞持续气道正压通气防治新生儿呼吸窘迫综合征效果显著,能降低患儿并发症的发生,减少抗生素的使用,利于患儿康复。
Objective To study the clinical efficacy of budesonide inhalation combined with corticosteroids in combination with nasal continuous positive airway pressure to prevent neonatal respiratory distress syndrome (ARDS). Methods Twenty neonates with respiratory distress syndrome were divided into study group and control group according to the digital randomization method, with 10 cases in each group. The control group was given Guer Su-Su mixture intratracheal intubation with nasal continuous positive airway pressure treatment, the study group on the basis of budesonide inhalation therapy. Blood gas analysis results before and after treatment were observed in two groups of children, and the situation of repeated use of Cureux and concurrent pneumonia was observed. Results The indexes of the study group at 1 and 6 h after treatment were significantly better than those of the control group (P <0.05). The recovery rate of the study group was significantly higher than that of the control group (P <0.05) The incidence of infection and re-use of sucrose was significantly less than that of the control group (P <0.05). Conclusions Budesonide inhalation combined with Gul-Su with nasal continuous positive airway pressure to prevent and treat neonatal respiratory distress syndrome has a significant effect, which can reduce the incidence of complications, reduce the use of antibiotics, and facilitate the recovery of children.