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本文报道钩吻总碱注射液对麻醉大鼠呼吸、血压、心电及脑电的影响，结果显示：钩吻总碱０．９ｍｇ／ｋｇ组对大鼠呼吸、血压、心电及脑电四项指标均无明显影响。１．８ｍｇ／ｋｇ组对呼吸及脑电无明显影响，但药后２０－４０ｍｉｎ时出现血压下降，心率减慢（Ｐ＜０．０５），６０ｍｉｎ后血压和心率逐渐恢复正常。３．６ｍｇ／ｋｇ组对呼吸、血压、心电和脑电均有显著影响（Ｐ＜０．０１）。说明该药随着剂量的增大，上述四项指标的抑制过程呈正变量效关系，提示临床使用该药时要严格控制剂量。
This article reported the effect of total ketozoleine injection on respiration, blood pressure, electrocardiogram and electroencephalogram in anesthetized rats. The results showed that the total concentration of konjac total base 0.9mg/kg on rats’ respiration, blood pressure, ECG and EEG. Item indicators have no significant effect. The 1.8mg/kg group had no significant effect on respiration and EEG, but the blood pressure decreased and the heart rate slowed down (P<0.05) after 20-40min. The blood pressure and heart rate gradually returned to normal after 60 minutes. The 3.6 mg/kg group had significant effects on respiration, blood pressure, ECG, and brain electricity (P<0.01). It shows that with the increase of dose, the above four indicators of the inhibition process is positive variable-response relationship, suggesting that the clinical use of the drug should be strictly controlled dose.