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急性T淋巴细胞白血病（ T-ALL）是进行性的血液系统恶性疾病，以 T细胞克隆增生、积聚和组织浸润为特点，好发于儿童和青少年，占儿童急性淋巴细胞白血病的10％～15％。 NOTCH1和磷脂酰肌醇3-激酶／丝氨酸／苏氨酸蛋白激酶（PI3K-Akt）信号通路及两者之间通过下游靶基因和靶蛋白实现的交互作用在T-ALL发生和发展中扮演重要角色。随着对这两条信号通路的认识逐渐深入， NOTCH1和PI3K-Akt信号通路成为治疗T-ALL的新靶点。“,”T cell acute lymphoblastic leukemia ( T-ALL) is a progressive hematological malignant disease featured with clonal proliferation,accumulation and tissue infiltration of T cells.T-ALL is the most common malignancy in children and adolescents,which accounts for 10%-15% of childhood acute lymphoblastic leu-kemia.The crosstalk between NOTCH1 and PI3K-Akt signal pathway through downstream target protein and target gene plays important roles in the development of T-ALL.Given the importance of NOTCH1 and PI3K-Akt signal pathway in the pathogenesis of T-ALL,they are becoming new and propitious targets for the treatment of T-ALL.