青霉素类药物与头孢菌素药有无交叉过敏问题? 青霉素由β-内酰胺环和饱和噻唑五元环组成基本母核。其主要的过敏决定簇是由β-内酰胺环开环后形成的青霉噻唑基。因不同的青霉素能生成含有相同的青霉噻唑衍生物,存在共同的抗原决定簇。所以,不同青霉素之间能呈现交叉过敏反应。头孢菌素由β-内酰胺环与二氢噻嗪六元环组成基本母核,其C_7位上的取代物是抗原决定簇。青 Penicillins and cephalosporin drug cross-allergy problems? Penicillin by β-lactam ring and saturated thiazole five-membered ring composed of the basic mother nucleus. Its major allergic determinant is the penicillin thiazolyl formed by the opening of the beta-lactam ring. Because different penicillins can produce the same penicillin-containing derivatives, there are common antigenic determinants. Therefore, different penicillin can show cross-allergic reactions. Cephalosporins by the β-lactam ring and dihydrothiazine six-membered ring composed of the basic mother nucleus, the substitution at the C_7 position is an antigenic determinant. green