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目的:分析丽水市中心医院癌症患者麻醉性镇痛药应用情况,为临床用药提供依据。方法:通过分析该院2010年1月-2011年1月期间癌症患者处方,采用WHO限定日剂量作为测定药物利用单位,以药物利用指数为指标对处方进行分析,评价该院癌症患者麻醉性镇痛药应用合理性。结果:786张处方,其中男性287例,占36.51%,女性499例,占63.49%。所用麻醉性镇痛药根据剂型及规格不同分为9种。在癌症疼痛用药组中,60岁以上老年患者应用盐酸哌替啶注射液所占比例明显高于非癌症疼痛用药组相应比例,应用麻醉性镇痛药所占比例也明显高于非癌症疼痛用药组相应比例。盐酸吗啡注射液DUI值明显<1,DUI=1.31,枸橼酸芬太尼注射液DUI=1.00,其他DUI值均低于1。结论:该院癌症患者麻醉性镇痛药应用较为合理,能够正确把握及理解WHO癌症病人三级止痛阶梯治疗方案。
Objective: To analyze the application of narcotic analgesics in patients with cancer in Lishui Central Hospital and provide the basis for clinical use. Methods: By analyzing the prescriptions of cancer patients from January 2010 to January 2011 in the hospital, the WHO defined daily dose was used as the unit of determination of drug use, and the index of drug use was used as an index to analyze the prescriptions to evaluate the patients’ Pain medication application rationality. Results: There were 786 prescriptions, of which 287 were male, accounting for 36.51% and 499 were female, accounting for 63.49%. Narcotic analgesics used according to different dosage forms and specifications are divided into 9 kinds. In the cancer pain medication group, the proportion of the application of pethidine hydrochloride injection in elderly patients over the age of 60 was significantly higher than that of the non-cancer pain medication group, and the proportion of the narcotic analgesics was also significantly higher than that of the non-cancer pain medication Group the corresponding ratio. Morphine hydrochloride injection DUI value was significantly <1, DUI = 1.31, fentanyl citrate injection DUI = 1.00, other DUI values were less than 1. Conclusion: The application of narcotic analgesics in cancer patients in this hospital is more reasonable and can correctly grasp and understand the three-stage analgesic ladder treatment plan of cancer patients in WHO.