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目的探讨老年冠状动脉粥样硬化性心脏病(冠心病)患者血栓调节蛋白(TM)与冠状动脉粥样硬化程度之间的关系。方法80例住院冠心病患者按螺旋CT冠状动脉钙化积分值分成4组:低度危险组42例,中度危险组8例,重度危险组24例,极度危险组6例。比较4组血浆TM值。结果4组间的血浆TM随着钙化总积分的增加而增加,差异均有统计学意义(均P<0.01)。相关分析结果表明,血浆TM值和冠状动脉钙化总积分呈正相关(r=0.957,P<0.01)。结论血浆TM水平是反映老年冠心痛患者内皮损伤的良好标志。也是评价冠状动脉粥样硬化狭窄程度的指标。
Objective To investigate the relationship between thrombomodulin (TM) and coronary atherosclerosis in elderly patients with coronary atherosclerotic heart disease (CHD). Methods 80 patients with coronary heart disease were divided into 4 groups according to the spiral CT coronary artery calcification score: 42 patients in low risk group, 8 patients in moderate risk group, 24 patients in severe risk group and 6 patients in extremely dangerous group. Four groups of plasma TM values were compared. Results The plasma TM increased with the increase of total score of calcification (all P <0.01). Correlation analysis showed that plasma TM value and total coronary artery calcification score was positively correlated (r = 0.957, P <0.01). Conclusion Plasma TM level is a good indicator of endothelial damage in elderly patients with coronary heart disease. It is also an indicator of the severity of coronary atherosclerosis.