论文部分内容阅读
目的探讨促皮质素(ACTH)治疗婴儿痉挛症(IS)前后脑电图的改变趋势,为病因学和治疗学研究提供依据。方法回顾性分析本院小儿神经科收治的44例经ACTH治疗的IS患儿临床资料、治疗前1、2 d及正规治疗14 d后的视频脑电图,对经ACTH治疗前后IS患儿脑电图的放电总数变化情况进行评估,并对其前额额区、中央顶区、枕区、中后颞区4个部位治疗后改善程度是否存在差异及哪个部位改善最明显进行研究。结果 ACTH治疗前后IS患儿脑电图的放电总数变化有统计学意义(Z=-5.217,P<0.05);前额额区、中央顶区、枕区、中后颞区4个部位治疗后较治疗前有改善(M=34.075,P<0.05);上述4个部位用SNK法分别进行两两比较,前额额区与其他部位比较差异均有统计学意义,中央顶区、枕区,中后颞区组两两比较差异均无统计学意义,前额额区的用药前后差值最小。结论 ACTH可明显改善IS的异常放电,其改善程度在各部位之间有差异,其中前额、额区较中央顶区、枕区、中后颞区差,可能与IS的病因和发病机制相关。
Objective To investigate the changes of electroencephalogram before and after treatment of corticotropin (ACTH) with infantile spasms (IS), and to provide evidence for the study of etiology and therapeutics. Methods A retrospective analysis of our hospital pediatric neurology admitted 44 cases of ACTH-treated children with IS clinical data, 1 d before treatment and 14 d after regular treatment of video EEG, before and after treatment of ACTH brain in children with IS The changes of the total discharge of the electrogram were evaluated. The differences of the improvement degree of the four parts in the forehead, central apical region, occipital region and mid-posterior temporal region after treatment were observed and the most obvious improvement were found. Results Before and after ACTH treatment, the total number of discharges of EEG in IS children was significantly changed (Z = -5.217, P <0.05). Compared with the control group, the frontal forehead, central apical region, occipital region and mid- Before treatment, there was improvement (M = 34.075, P <0.05). The above four sites were compared with each other by SNK method respectively. There was significant difference between the forehead and other sites. The central apical region, occipital region, There was no significant difference between the two groups in the temporal region group, and the difference between before and after the forehead area was the smallest. Conclusions ACTH can significantly improve the abnormal discharge of IS. There is a difference in the degree of improvement between different parts. The difference of forehead and frontal area from the central apical area, occipital area, medial and posterior temporal area may be related to the etiology and pathogenesis of IS.