微透析技术是一项越来越被广泛使用的在体研究技术,其遵循透析原理,以探针为基础取样,可连续检测局部组织细胞外液的药物浓度,能满足常规的药代动力学/药效学(PK-PD)研究。本文就其在靶组织局部药物浓度检测中的应用作一简要介绍。 Microdialysis technology is a more and more widely used on-the-art technique that follows the principle of dialysis and uses probe-based sampling to continuously detect drug concentrations in the extracellular fluid of the local tissue to meet routine pharmacokinetics / Pharmacodynamics (PK-PD) study. This article gives a brief introduction of its application in the detection of local drug concentration in target tissues.