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目的:探讨湿困脾胃证模型肠黏膜屏障功能障碍及平胃散的修复作用。方法:40只大鼠随机分为空白对照组、模型组、治疗组、自然恢复组,每组10只.建立湿困脾胃证大鼠模型,观测各组大鼠血清D-乳酸含量、血清二胺氧化酶(DAO)活性、空肠组织匀浆谷氨酰胺(Gln)浓度和Na+-K+-ATPase,Ca2+-ATPase活力变化情况。结果:与空白组相比,模型组大鼠血清D-乳酸含量升高(P<0.01),空肠Gln浓度、Na+-K+-ATPase,Ca2+-ATPase活性降低(P<0.01);平胃散治疗后各指标均有恢复,且效果都好于自然恢复组。结论:湿困脾胃证能造成肠黏膜屏障功能及离子泵出现障碍,平胃散对其有明显修复作用。
Objective: To investigate the intestinal mucosal barrier dysfunction and the repair effect of Pingwei San in wet-stool type of stomach syndrome. Methods: Forty rats were randomly divided into blank control group, model group, treatment group and spontaneous recovery group, with 10 rats in each group.The rats in wet-trap stomach-dampness syndrome model were established, serum D-lactate concentration, (DAO) activity, glutamine (Gln) concentration and Na + -K + -ATPase, Ca2 + -ATPase activity in jejunum tissue. Results: Compared with the blank group, the content of D-lactic acid in the model group increased (P <0.01), the concentration of Gln, Na + -K + -ATPase and Ca2 + -ATPase in jejunum decreased (P <0.01) The indicators have recovered, and the effect is better than the natural recovery group. Conclusion: The syndrome of dampness and qi stagnation stomach can cause the barrier function of intestinal mucosa and the obstacles of ion pump, and Pingweisan can obviously repair it.