目的　用事件相关电位 (ERP)脑电地形图技术 ,研究睡眠呼吸暂停综合征 (OSAS)睡眠间断性低血氧对工作记忆损害机制。方法　采用探针提取方法并加以改良。轻、重症患者各 12例 ;同期设 2 0名正常对照者。结果　ERP结果显示 ,对照组辨异效应主要分布于右额 [F4 ,(2 .2± 2 .7)μV]及枕部 [O1,(0 .8± 3.5 ) μV ;O2 ,(0 .7± 3.5 ) μV],辨同效应则以顶部为著 [P3,(7.0± 3.0 ) μV ;P4 ,(6 .9± 3.1) μV ]。轻症患者前额部辩异效应损害明显 [F4 ,(5 .0± 4 .5 ) μV ;F3,(6 .0± 4 .5 ) μV ;P <0 .0 1],而重症组辨异及辨同效应均受损 [F3,(5 .3± 2 .4 ) μV ;F4 ,(4.9± 3.1) μV ;P3,(3.6± 3.5 )μV ;P4 ,(4.6± 2 .7) μV ;P <0 0 5 ]。脑电地形图与上述结果一致。 结论　OSAS患者前额ERP辨异效应的变化反映了中央执行系统功能对缺氧性损害十分敏感。 Objective To investigate the mechanism of intermittent hypoxemia in sleep apnea syndrome (OSAS) on working memory by using ERP (EEG) technique. Methods The method of probe extraction was used and improved. Light and severe cases in each of 12 cases; the same period set 20 normal controls. Results The results of ERP showed that the discrimination effect of the control group was mainly distributed in the right forebrain (F4, (2.2 ± 2.7) μV] and occipital [O1, (0.8 ± 3.5) μV; O2, (0.7 ± 3.5) μV], and the same synergistic effect was at the top [P3 (7.0 ± 3.0) μV; P4, (6.9 ± 3.1) μV]. The severity of forebrain debridement was significantly impaired in mild subjects [F4, (5.0 ± 4.5) μV; F3, (6.0 ± 4.5) μV; P <0.01) And the same effect were all impaired [F3, (5.3 ± 2.4 μV; F4, (4.9 ± 3.1) μV; P3, (3.6 ± 3.5) μV; P <0 0 5]. EEG topographic map with the above results. Conclusions The changes of forehead ERP discrimination effect in OSAS patients reflect that central executive system function is very sensitive to hypoxic damage.